Friday, November 1, 2013

Bellator 106 open workouts: Pat Curran vs. Daniel Straus


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Source: http://www.mmafighting.com/2013/11/1/5054988/bellator-106-open-workouts-pat-curran-vs-daniel-straus
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Oligomeric proanthocyanidin suppresses the death of retinal ganglion cells

Oligomeric proanthocyanidin suppresses the death of retinal ganglion cells


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PUBLIC RELEASE DATE:

31-Oct-2013



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Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research






The death of retinal ganglion cells is a hallmark of many optic neurodegenerative diseases such as glaucoma and retinopathy. Oxidative stress is one of the major reasons to cause the cell death. A latest study, published in the Neural Regeneration Research (Vol. 8, No. 25, 2013), has shown that grape seed extract can protect retinal ganglion cells against oxidative stress-induced apoptosis. In this study, Prof. Kwok-Fai So, an academician of Chinese Academy of Sciences, and Prof. Daxiang Lu from Jinan University, China show that oligomeric proanthocyanidin, enriched in grape seeds, has a protective effect on retinal ganglion cells against oxidative stress-induced injury, as confirmed by using both RGC-5 cell lines and retinal explant culture. These findings imply a potential application of oligomeric proanthocyanidin in the clinical treatment of many neural diseases, from glaucoma, ischemia to neurodegenerative disease.


###

Article: " Oligomeric proanthocyanidin protects retinal ganglion cells against oxidative stress-induced apoptosis," by Hui Wang1, 2, Chanjuan Zhang1, 2, Dan Lu1, 2, Xiaoming Shu1, Lihong Zhu1, 2, Renbing Qi1, Kwok-Fai So2, Daxiang Lu1, Ying Xu2 (1 Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of China, Jinan University School of Medicine, Guangzhou 510632, Guangdong Province, China; 2 GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, Guangdong Province, China)


Wang H, Zhang CJ, Lu D, Shu XM, Zhu LH, Qi RB, So KF, Lu DX, Xu Y. Oligomeric proanthocyanidin protects retinal ganglion cells against oxidative stress-induced apoptosis. Neural Regen Res. 2013;8(25):2317-2326.


Contact:

Meng Zhao

eic@nrren.org

86-138-049-98773

Neural Regeneration Research

http://www.nrronline.org/

Full text: http://www.sjzsyj.org/CN/article/downloadArticleFile.do?attachType=PDF&id=704




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Oligomeric proanthocyanidin suppresses the death of retinal ganglion cells


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

31-Oct-2013



[


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]


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Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research






The death of retinal ganglion cells is a hallmark of many optic neurodegenerative diseases such as glaucoma and retinopathy. Oxidative stress is one of the major reasons to cause the cell death. A latest study, published in the Neural Regeneration Research (Vol. 8, No. 25, 2013), has shown that grape seed extract can protect retinal ganglion cells against oxidative stress-induced apoptosis. In this study, Prof. Kwok-Fai So, an academician of Chinese Academy of Sciences, and Prof. Daxiang Lu from Jinan University, China show that oligomeric proanthocyanidin, enriched in grape seeds, has a protective effect on retinal ganglion cells against oxidative stress-induced injury, as confirmed by using both RGC-5 cell lines and retinal explant culture. These findings imply a potential application of oligomeric proanthocyanidin in the clinical treatment of many neural diseases, from glaucoma, ischemia to neurodegenerative disease.


###

Article: " Oligomeric proanthocyanidin protects retinal ganglion cells against oxidative stress-induced apoptosis," by Hui Wang1, 2, Chanjuan Zhang1, 2, Dan Lu1, 2, Xiaoming Shu1, Lihong Zhu1, 2, Renbing Qi1, Kwok-Fai So2, Daxiang Lu1, Ying Xu2 (1 Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of China, Jinan University School of Medicine, Guangzhou 510632, Guangdong Province, China; 2 GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, Guangdong Province, China)


Wang H, Zhang CJ, Lu D, Shu XM, Zhu LH, Qi RB, So KF, Lu DX, Xu Y. Oligomeric proanthocyanidin protects retinal ganglion cells against oxidative stress-induced apoptosis. Neural Regen Res. 2013;8(25):2317-2326.


Contact:

Meng Zhao

eic@nrren.org

86-138-049-98773

Neural Regeneration Research

http://www.nrronline.org/

Full text: http://www.sjzsyj.org/CN/article/downloadArticleFile.do?attachType=PDF&id=704




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Source: http://www.eurekalert.org/pub_releases/2013-10/nrr-ops103113.php
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Zoe Saldana & Marco Perego: Loved Up in LA

Publicly displaying their affection freely, Zoe Saldana and Marco Perego showed up at The Grove for some shopping on Thursday (October 31).


The “Avatar” stunner and her handsome hubby were joined by their dog Mugsy as they made their rounds while fans and shutterbugs watched nearby.


Ms. Saldana donned a casual shawl over a printed blue jumpsuit and black sunglasses and smiled non-stop while holding her Italian stud’s hand.


And of course there was plenty of nuzzling and smooching along the way as these two are definitely still in their honeymoon stage.


Source: http://celebrity-gossip.net/zoe-saldana/zoe-saldana-marco-perego-loved-la-953655
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How to Build a Fame Monster

The following is excerpted from Blockbusters: Hit-Making, Risk-Taking, and the Big Business of Entertainment, by Anita Elberse, published by Henry Holt & Co.










Standing backstage at Boston’s sold-out TD Garden in March 2011 during Lady Gaga’s smash-hit tour, the Monster Ball, her manager, Troy Carter, paused a moment to take it all in. “It is amazing how far we have come in such a short time,” he said.










After emerging on the pop-music scene in 2008—touring as a supporting act for New Kids on the Block, a boy band beyond its glory years—Lady Gaga broke through in early 2009, when her singles “Just Dance” and “Poker Face” topped international charts. She rapidly became one of the biggest names in entertainment, sweeping up Grammys and Video Music Awards and selling tens of millions of singles. In 2011, Forbes ranked her first on its Celebrity 100 list, ahead of Oprah Winfrey.












As is the case with most “overnight successes,” Gaga’s ascent had been a long time in the making. In the early days of her career, through a relentless touring schedule—for months on end, she put on seven to eight shows a week, sometimes performing three times per night, in clubs around the U.S. and Canada—Gaga had built a fan base with a strong core. “We wanted to build her fan base from the ground up,” Carter said. “Once the audience feels they own something, they are going to run with it, and do the work for you.” She relied heavily on Facebook, Twitter, and YouTube to spread word of mouth and strengthen her connection with her fans—her ”little monsters,” as she called them. She turned out to be extraordinarily skilled at doing so: By 2011, Gaga was the most popular living person on Facebook and the most followed person on Twitter.














Given her extraordinary success with a grassroots approach to launching her music, one might have assumed that Gaga, Carter, and her label, Interscope, would stick with such a strategy in 2011 for her third album, Born This Way. Yet the Born This Way launch compared more to “a movie blockbuster in the summer months, like Avatar,” as Interscope’s vice chairman Steve Berman put it. “With an artist of Gaga’s caliber,” Carter said, “reaching full potential means doing things on an enormous scale.” He knew that the launch he had in mind would have to go beyond traditional music-distribution channels and would test the limits of what a record label—even one the size of Universal Music Group—could afford. Carter and his team likewise pursued a blockbuster strategy for Gaga's forthcoming record, ARTPOP, due Nov. 11.










Most leading entertainment businesses operate on such a blockbuster model: making risky bets on the development of a select few products, then increasing the stakes by investing a great deal of money in distributing and promoting those products as widely as possible, all with an eye toward opening as big as they can. Companies often set marketing budgets at high levels well before they know how those products will be received in the marketplace. But what’s the rationale? Why would the team behind Lady Gaga want to move away from a word-of-mouth-driven launch that worked so well for them in the past? With Gaga’s new album likely to sell like hot cakes, wouldn’t record label executives prefer to save on any unnecessary marketing expenditures?










Launching entertainment products—albums, movies, television shows, video games, books—using what marketers call a “limited” or “grass-roots” release strategy has undeniable advantages. The basic idea is to gradually discover what level of marketing spending is most appropriate. It is all about being as efficient as possible with the available resources. For a movie, for example, a limited-release strategy generally means that it debuts on only a few screens in major cities, and is supported with print and online advertisements in those regions. The goal is to attract not the largest but rather the right audience to the product, in the hopes that those early customers will in turn spread positive word of mouth and help draw in new audiences. Only if the product takes off—or shows some signs of being on the verge of taking off—will the producer gradually increase the distribution coverage or intensity and support the product with more advertising to further enhance growth. The principle is to spend sizable amounts of money on the marketing of only those products that are worth it—those that truly have a chance of success in the marketplace.










Lady Gaga’s first recordings were released in this fashion. When her first single, “Just Dance,” was released in April 2008, gaining traction proved difficult. “We could not get it played on pop radio,” Carter recalled. “Mainstream radio stations told us it was too much of a dance song for them.” Bobby Campbell, chief marketing officer at Carter’s management firm Atom Factory, agreed: “Dance music simply was not on the air in Top 40 radio.”










So Carter relied on an intense schedule of live performances targeted at communities that seemed especially receptive to her music. “The gay community seemed to stick to her, and that resonated with her personally, so gay clubs were a natural fit to start the work,” Campbell said. “It was about finding different groups: the gay community, the dance community, the club-going community, the fashion community, the art community, and developing those into a larger pool of Gaga fans. So when Interscope made some headway with radio later on, we had this really strong core of fans who had been following her for months, and who felt they were part of the reason why she was successful.”










Jimmy Iovine, Interscope’s chairman, talks about capitalizing on “sparks”: The idea is that if an entertainment product resonates with audiences in a given market, that market can, with the right kind of support, become a launching pad for a wider rollout.














Source: http://www.slate.com/articles/business/when_big_businesses_were_small/2013/10/lady_gaga_artpop_how_the_icon_s_grass_roots_approach_to_stardom_turned_into.html
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Hangouts v2 preinstalled on Nexus 5, updated in Play Store in coming weeks

Hangouts v2 Hangouts v2

New information revealed about SMS integration, statuses and sharing options

Google announced at an event this week that new features would be coming in the latest version of Hangouts, and now we have a better idea of when and specifically what we'll be getting. First up is SMS and MMS integration — Google says you'll be able to receive text messages in Hangouts, and you can even import existing conversations when you make the move. SMS support also extends to group texts and emoji support between Android and iPhone.

You will also be able to send animated GIFs in Hangouts, including Auto Awesome animated photos made through Google+. Even further, you can now set status indicators showing what device you're currently using, whether or not you're in a call and what your mood is (if you're into that kinda thing). You'll also be able to share your granular location on a map (shown above).

read more


    






Source: http://feedproxy.google.com/~r/androidcentral/~3/hD0Gyte9D0I/story01.htm
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Bats confirmed as SARS origin

Bats confirmed as SARS origin


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30-Oct-2013



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Contact: Sally Corinaldi
sally.corinaldi@csiro.au
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CSIRO Australia





A team of international scientists has isolated a very close relative of the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) from horseshoe bats in China, confirming them as the origin of the virus responsible for the 2002-3 pandemic.

The SARS-CoV pandemic killed 774 people of the 8094 people infected, a case fatality ratio of almost 10 per cent. With cases diagnosed across the world, the pandemic had an impact on international travel and trade.


The research team, led by Professor Shi Zhengli from Wuhan Institute of Virology, Chinese Academy of Sciences and including CSIRO and Duke-NUS scientist Professor Linfa Wang, have just had their breakthrough results published in Nature.

While researchers globally have previously used genetic sequencing to demonstrate that bats are the natural reservoirs of SARS-like CoVs, this is the first time that live virus has been successfully isolated from bats to definitively confirm them as the origin of the virus.


The team successfully isolated a SARS-like CoV, named SL-CoV WIV1, directly from faecal samples of Chinese Horseshoe bats using the world renowned bat virus isolation methodology developed by scientists at CSIRO's Australian Animal Health Laboratory in Geelong.


The results will help governments design more effective prevention strategies for SARS and similar epidemics.


Horseshoe bats are found around the world, including Australia and play an important ecological role. Their role in SARS-CoV transmission highlights the importance of protecting the bat's natural environment so they are not forced into highly populated urban areas in search of food.


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Bats confirmed as SARS origin


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PUBLIC RELEASE DATE:

30-Oct-2013



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Contact: Sally Corinaldi
sally.corinaldi@csiro.au
61-352-275-203
CSIRO Australia





A team of international scientists has isolated a very close relative of the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) from horseshoe bats in China, confirming them as the origin of the virus responsible for the 2002-3 pandemic.

The SARS-CoV pandemic killed 774 people of the 8094 people infected, a case fatality ratio of almost 10 per cent. With cases diagnosed across the world, the pandemic had an impact on international travel and trade.


The research team, led by Professor Shi Zhengli from Wuhan Institute of Virology, Chinese Academy of Sciences and including CSIRO and Duke-NUS scientist Professor Linfa Wang, have just had their breakthrough results published in Nature.

While researchers globally have previously used genetic sequencing to demonstrate that bats are the natural reservoirs of SARS-like CoVs, this is the first time that live virus has been successfully isolated from bats to definitively confirm them as the origin of the virus.


The team successfully isolated a SARS-like CoV, named SL-CoV WIV1, directly from faecal samples of Chinese Horseshoe bats using the world renowned bat virus isolation methodology developed by scientists at CSIRO's Australian Animal Health Laboratory in Geelong.


The results will help governments design more effective prevention strategies for SARS and similar epidemics.


Horseshoe bats are found around the world, including Australia and play an important ecological role. Their role in SARS-CoV transmission highlights the importance of protecting the bat's natural environment so they are not forced into highly populated urban areas in search of food.


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Source: http://www.eurekalert.org/pub_releases/2013-10/ca-bca103013.php
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Sandra Bullock and Melissa McCarthy Take Louis out as Gorton's Fishermen

Dressing up to go harpooning on the high seas for Halloween (October 31), Sandra Bullock and Melissa McCarthy took little Louis out for Trick-Or-Treating as Gorton's Fishermen.


Looking legit in full fisherman's rubbers, complete with gray beards, "The Heat" co-stars were great sports walking Sandra's adoptive son around the neighborhood. He was dressed as a scary skeleton, holding a bucket for his candy as they went.


In related news, the 49-year-old mommy is working hard as a voice actor for the upcoming "Despicable Me" spinoff, "Minions." Set for release on July 10th of 2014, the "Gravity" beauty will play the voice of the seductive Scarlett Overkill.


According to the synopsis, "Dr. Gru is recruited by an organization to stop Scarlet Overkill, a super-villain who, alongside her inventor husband Herb, hatches a plot to take over the world."


Source: http://celebrity-gossip.net/sandra-bullock/sandra-bullock-and-melissa-mccarthy-take-louis-out-gortons-fishermen-953397
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This freakish skinless body is actually a synthetic human cadaver

This freakish skinless body is actually a synthetic human cadaver

Though it may look like it, this is not a still frame from a torture porn movie directed by the sadist Eli Roth. Instead, it's the new synthetic cadaver that medical students are now using to get their learn on. Instead of poking humans or operating on animals, medical students can play doctor with these frighteningly freakish zombie beasts.

Read more...


    
Source: http://feeds.gawker.com/~r/gizmodo/full/~3/yq8lp29qc6Y/@caseychan
Category: Ed Sheeran   Bill De Blasio   Alison Pill   Madden 25   Marion Bartoli  

Kerry: U.S. spying 'reached too far' in some cases


Washington (AFP) - The United States has said in some cases its surveillance program has gone too far, an unprecedented admission in its tense row with Europe over US spying against allies.

After 10 days of scandal with key European allies, a statement Thursday by Secretary of State John Kerry was the first to explicitly acknowledge overstepping by US intelligence.

Kerry justified the surveillance in broad terms, citing the September 11, 2001 terror attacks in the United States, as well as attacks in London, Madrid and elsewhere to argue that the US and other countries have had to come together to fight "extremism in the world that is hell-bent and determined to try to kill people and blow people up and attack governments."

He said US intelligence has since 2001 averted attacks with intercepts of communications. But he acknowledged, without going into specifics, that at times it has been too much.

Kerry also sought to give assurances that such steps, which have roiled close allies like Germany, would not be repeated.

"I assure you, innocent people are not being abused in this process, but there's an effort to try to gather information," Kerry told a London conference via video link. "And yes, in some cases, it has reached too far inappropriately."

"And the president, our president, is determined to try to clarify and make clear for people, and is now doing a thorough review in order that nobody will have the sense of abuse," he said.

Kerry added that what Washington was trying to do was, in a "random way," find ways of determining if there were threats that needed responding to.

"And in some cases, I acknowledge to you, as has the president, that some of these actions have reached too far, and we are going to make sure that does not happen in the future," he said.

Recent allegations and reports of widespread spying by the US National Security Agency have sparked a major rift in trans-Atlantic ties.

This week German Chancellor Angela Merkel angrily confronted President Barack Obama with allegations that the NSA was snooping on her phone, saying it would amount to a "breach of trust."

A German intelligence delegation and a separate group of EU lawmakers were in the US capital Wednesday to confront their American allies about the alleged bugging.

Kerry's remarks -- released in a State Department transcript -- came in response to a question addressed to both him and British Foreign Secretary William Hague about government surveillance.

Kerry spent a good portion of his answer justifying the collection of data as necessary due to the threat of terrorism and suggested Washington was not alone in doing so.

"Many, many, many parts of the world have been subject to these terrorist attacks," he said.

"And in response to them, the United States and others came together -- others, I emphasize to you -- and realized that we're dealing in a new world where people are willing to blow themselves up."

He added: "We have actually prevented airplanes from going down, buildings from being blown up, and people from being assassinated because we’ve been able to learn ahead of time of the plans."

Kerry also lashed out at some of the reporting about alleged spying, sparked by leaks from fugitive former NSA contractor Edward Snowden, wanted by Washington on espionage charges.

"Just the other day... there was news in the papers of 70 million people being listened to. No, they weren't. It didn't happen," Kerry said.

"There's an enormous amount of exaggeration in this reporting from some reporters out there."

US intelligence chiefs have said these reports are based on a misinterpretation of an NSA slide leaked to the media by Snowden.

Rather than siphoning off the records of tens of millions of calls in Europe, as the slide seems to suggest, they argue that the data was in many cases gathered and shared by European agencies.

Still, fresh US spy allegations keep cropping around the world on a near daily basis.

Indonesia summoned the Australian ambassador in Jakarta Friday over a "totally unacceptable" report that his embassy was among diplomatic posts in Asia being used in a vast American surveillance operation.

The Sydney Morning Herald newspaper, amplifying an earlier report by the German magazine Der Spiegel, said earlier this week that a top-secret map leaked by Snowden showed 90 US surveillance facilities at diplomatic missions worldwide.

The paper also reported that Australian embassies in Asia were being used as part of the US-led spying network.

On Wednesday, meanwhile, a report in the Washington Post alleged that NSA technicians had tapped into Yahoo and Google data centers around the world, winning access to vast amounts of private data.

The report said a program dubbed MUSCULAR, operated with the NSA's British counterpart GCHQ, can intercept data directly from the fiber-optic cables used by the US Internet giants.

Source: http://news.yahoo.com/kerry-says-cases-us-spying-reached-too-far-020926694.html
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Antonio Rogerio Nogueira injured, out of Alexander Gustafsson fight


Just five days after UFC president Dana White announced a light heavyweight bout between Antonio Rogerio Nogueira and Alexander Gustafsson for the promotion's return to London, England on March 8, the UFC has been forced to change its plans.


"Minotouro" has withdrawn from the fight due to a lingering back injury, sources close to the situation confirmed with MMAFighting.com before White also confirmed the news with Ariel Helwani.


White added that there are no plans for Gustafsson's next fight yet. Gustafsson's team also said it heard the news but didn't know who the Swedish fighter will draw next.


Nogueira, who is expected to be ready to fight again in May, hasn't fought since his unanimous decision victory over Rashad Evans at UFC 156 in February. During his UFC career, the Brazilian light heavyweight has pulled out of multiple bouts due to injury, cancelling matches against Rich Franklin, Mauricio Rua, as well as Gustafsson back in April 2012. The same back injury forced him out of his UFC 161 rematch against Rua.


Gustafsson vs. Nogueira was scheduled to headline the first of six events in Europe next year. The card will take place at the O2 Arena in London.


Source: http://www.mmafighting.com/2013/10/31/5052980/antonio-rogerio-nogueira-injured-out-of-alexander-gustafsson-fight
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Driver expects to fight Google Glass ticket

(AP) — A Southern California woman cited for wearing Internet-connected eyeglasses while driving plans to contest the citation.

Cecilia Abadie was pulled over for speeding Tuesday evening in San Diego, when a California Highway Patrol officer noticed she was wearing Google Glass and tacked on a citation usually given to drivers who may be distracted by a video or TV screen.

The lightweight eyeglasses, which are not yet widely available to the public, feature a hidden computer and a thumbnail-size transparent display screen above the right eye. Users can scan maps for directions — as well as receive web search results, read email and engage in video chats — without reaching for a smartphone.

Abadie, a software developer, said in an interview that she was not using her Google Glass when she was pulled over for allegedly going about 80 mph in a 65 mph zone on the drive home to Temecula after visiting a friend.

"The Glass was on, but I wasn't actively using it" to conserve the battery, she said.

Abadie expressed surprise that wearing the glasses while driving would be illegal and said she's "pretty sure" she will fight the ticket. First, she said, she needs to seek legal counsel. In the flurry of online commentary her traffic stop has generated, several people saying they are attorneys offered their services.

"The law is not clear, the laws are very outdated," Abadie said, suggesting that navigating with the device could be less distracting than with a GPS unit or phone.

"Maybe Glass is more a solution to the cellphone problem than a problem," she said.

It's unclear whether a citation for Google Glass has been issued before. The CHP said it is not sure whether an officer within its own ranks has written one, and an agency spokesman pointed out hundreds of law enforcement agencies in California alone can write traffic tickets.

Legislators in at least two states, Delaware and West Virginia, have introduced bills that would specifically ban driving with Google Glass. Authorities in the United Kingdom are mulling a similar ban.

About 10,000 units have been distributed so far in the United States to "pioneers," and this week Google announced another 30,000 would be available for $1,500 apiece. Abadie said she got hers in May and has become an "evangelist" for the technology.

A spokesman for Google did not reply to a request for comment. On its website, Google says this about using the headgear while driving: "Read up and follow the law. Above all, even when you're following the law, don't hurt yourself or others by failing to pay attention to the road."

___

Associated Press researcher Rhonda Shafner in New York contributed to this report.

___

Follow Justin Pritchard at https://twitter.com/lalanewsman

Associated PressSource: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-10-31-Google%20Glass%20Ticket/id-7025da1bebf1422d80e8b7854adec5b2
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Do We Have a Legal Right to Light?

Do We Have a Legal Right to Light?

With supertall towers popping up along Central Park's southern edge like wildly expensive luxury mushrooms, Manhattan's largest park is about to be cast into shadow—some as long as half a mile. The real estate boom is stirring up a debate: Do we have a "right to light"?

Read more...


    






Source: http://feeds.gawker.com/~r/gizmodo/full/~3/yQ8FN_dI3Gg/do-we-have-a-legal-right-to-light-1455302177
Category: steve bartman   Brant Daugherty   joe flacco   Jason Heyward   leah remini