Friday, November 1, 2013

Oligomeric proanthocyanidin suppresses the death of retinal ganglion cells

Oligomeric proanthocyanidin suppresses the death of retinal ganglion cells


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PUBLIC RELEASE DATE:

31-Oct-2013



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Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research






The death of retinal ganglion cells is a hallmark of many optic neurodegenerative diseases such as glaucoma and retinopathy. Oxidative stress is one of the major reasons to cause the cell death. A latest study, published in the Neural Regeneration Research (Vol. 8, No. 25, 2013), has shown that grape seed extract can protect retinal ganglion cells against oxidative stress-induced apoptosis. In this study, Prof. Kwok-Fai So, an academician of Chinese Academy of Sciences, and Prof. Daxiang Lu from Jinan University, China show that oligomeric proanthocyanidin, enriched in grape seeds, has a protective effect on retinal ganglion cells against oxidative stress-induced injury, as confirmed by using both RGC-5 cell lines and retinal explant culture. These findings imply a potential application of oligomeric proanthocyanidin in the clinical treatment of many neural diseases, from glaucoma, ischemia to neurodegenerative disease.


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Article: " Oligomeric proanthocyanidin protects retinal ganglion cells against oxidative stress-induced apoptosis," by Hui Wang1, 2, Chanjuan Zhang1, 2, Dan Lu1, 2, Xiaoming Shu1, Lihong Zhu1, 2, Renbing Qi1, Kwok-Fai So2, Daxiang Lu1, Ying Xu2 (1 Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of China, Jinan University School of Medicine, Guangzhou 510632, Guangdong Province, China; 2 GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, Guangdong Province, China)


Wang H, Zhang CJ, Lu D, Shu XM, Zhu LH, Qi RB, So KF, Lu DX, Xu Y. Oligomeric proanthocyanidin protects retinal ganglion cells against oxidative stress-induced apoptosis. Neural Regen Res. 2013;8(25):2317-2326.


Contact:

Meng Zhao

eic@nrren.org

86-138-049-98773

Neural Regeneration Research

http://www.nrronline.org/

Full text: http://www.sjzsyj.org/CN/article/downloadArticleFile.do?attachType=PDF&id=704




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Oligomeric proanthocyanidin suppresses the death of retinal ganglion cells


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

31-Oct-2013



[


| E-mail

]


Share Share

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research






The death of retinal ganglion cells is a hallmark of many optic neurodegenerative diseases such as glaucoma and retinopathy. Oxidative stress is one of the major reasons to cause the cell death. A latest study, published in the Neural Regeneration Research (Vol. 8, No. 25, 2013), has shown that grape seed extract can protect retinal ganglion cells against oxidative stress-induced apoptosis. In this study, Prof. Kwok-Fai So, an academician of Chinese Academy of Sciences, and Prof. Daxiang Lu from Jinan University, China show that oligomeric proanthocyanidin, enriched in grape seeds, has a protective effect on retinal ganglion cells against oxidative stress-induced injury, as confirmed by using both RGC-5 cell lines and retinal explant culture. These findings imply a potential application of oligomeric proanthocyanidin in the clinical treatment of many neural diseases, from glaucoma, ischemia to neurodegenerative disease.


###

Article: " Oligomeric proanthocyanidin protects retinal ganglion cells against oxidative stress-induced apoptosis," by Hui Wang1, 2, Chanjuan Zhang1, 2, Dan Lu1, 2, Xiaoming Shu1, Lihong Zhu1, 2, Renbing Qi1, Kwok-Fai So2, Daxiang Lu1, Ying Xu2 (1 Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of China, Jinan University School of Medicine, Guangzhou 510632, Guangdong Province, China; 2 GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, Guangdong Province, China)


Wang H, Zhang CJ, Lu D, Shu XM, Zhu LH, Qi RB, So KF, Lu DX, Xu Y. Oligomeric proanthocyanidin protects retinal ganglion cells against oxidative stress-induced apoptosis. Neural Regen Res. 2013;8(25):2317-2326.


Contact:

Meng Zhao

eic@nrren.org

86-138-049-98773

Neural Regeneration Research

http://www.nrronline.org/

Full text: http://www.sjzsyj.org/CN/article/downloadArticleFile.do?attachType=PDF&id=704




[ Back to EurekAlert! ]

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| E-mail


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]

 


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-10/nrr-ops103113.php
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